Integrated Molecular Analysis Approaches to Uncover Clinically Actionable Gene Targets and Molecular Markers


April 17 @ 3:00 pm 4:00 pm EDT

Spotlight Theater A | Presented by Cellecta


Presenter: Alex Chenchik, PhD
Mountain View, California

Presenter: Gus Frangou, PhD
Roswell Park Comprehensive Cancer Center
Molecular and Cellular Biology
Assistant Professor of Oncology
Buffalo, New York


Mutation analysis, expression profiling, and genetic screening have been instrumental in understanding cancer biology and tumorigenesis. However, it is often difficult to transition results from these molecular studies to the clinic. This session will present examples showing how expression profiling combined with TCR/BCR clonotype analysis, and in vivo CRISPR mutagenic screening using barcoded libraries guide libraries are able to uncover genetic targets with clinical and therapeutic relevance.

Speaker 1: Gus Frangou, PhD, Assistant Professor of Oncology and a Member of the Department of Molecular and Cellular Biology at Roswell Park Comprehensive Cancer Center, Buffalo, NY.

Talk: An integrated multi-omics approach to identify molecular regulatory mechanisms in breast cancer development and progression

Speaker 2: Alex Chenchik, PhD, President & Chief Scientific Officer, Cellecta

Talk: Adaptive Immune Receptor Profiling for Biomarker Discovery

Introductory Remarks & Moderator: Paul Diehl, PhD, Chief Operating Officer, Cellecta

This Exhibitor Spotlight Theater is a promotional activity and is not approved for continuing education credit. The content of this Exhibitor Spotlight Theater and opinions expressed by presenters are those of the sponsor or presenter and are not of the American Association for Cancer Research® (AACR).