More than 30 oral and poster presentations at the AACR Annual Meeting 2023 will be simultaneously published as articles in AACR journals, reflecting the high number of meritorious abstracts submitted for presentation at the meeting. The studies below, listed by day with session/presentation details, will be concurrently published in the AACR journals noted. Direct links to the journal articles will be available here as they are published.

SUNDAY, APRIL 16

Oral Presentation

Oral Presentation: Landscape of 4,506 pan-cancer samples harboring BRAF^V600E mutations, and NTRK/RET Fusions from 137,401 adult patients with cancer: Clinical implications for tissue agnostic therapies
Minisymposium: Advancing Cancer Research Through an International Cancer Registry: AACR Project GENIE Use Cases, 3 – 5 p.m. ET
Location: Room W230, Convention Center
Journal: Clinical Cancer Research

Poster Presentations

Poster Presentation: Evaluation of a transcriptomics-based precision oncology platform for patient-therapy alignment in treatment resistant malignancies
Poster Session: Mathematical Modeling of Tumor Growth and Treatment Response, 1:30 – 5 p.m. ET
Poster Location: Section 31, Board 7, Presentation 849
Journal: Cancer Discovery

Poster Presentation: Comprehensive analysis of 3,600 small cell lung cancer cases reveals rare genetic subtypes and multiple mechanisms of histological transformation
Poster Session: Analyses Using Clinical and Genomic Databases, 1:30 – 5 p.m. ET
Poster Location: Section 38, Board 14, Presentation 931
Journal: Cancer Discovery

Poster Presentation: High major histocompatibility complex class I expression overcomes cancer immunotherapy resistance due to interferon gamma signaling pathway defects
Poster Session: Oncolytic Viruses, Anticancer Vaccines, and Other Immunomodulatory Therapies, 1:30 – 5 p.m. ET
Poster Location: Section 24, Board 27, Presentation 707
Journal: Cancer Immunology Research

Poster Presentation: Metabolic reprogramming driven by IGF2BP3-COX6B2 axis promotes acquired resistance to EGFR-TKIs in non-small lung cancer
Poster Session: Drug Resistance in Molecular Targeted Therapies 2, 1:30 – 5 p.m. ET
Poster Location: Section 15, Board 10, Presentation 415
Journal: Cancer Research

Poster Presentation: Distinct Nrf2 signaling thresholds mediate lung tumor initiation and progression
Poster Session: Mouse Models of Human Cancer, 1:30 – 5 p.m. ET
Poster Location: Section 1, Board 12, Presentation 12
Journal: Cancer Research

MONDAY, APRIL 17

Oral Presentations

Oral Presentation: Forecasting pancreatic carcinogenesis through spatial multi-omics
Plenary Session: Early Detection and Interception of Cancer, 8 – 10 a.m. ET
Location: W Hall A2-3, Convention Center
Journal: Cancer Discovery

Oral Presentation: METTL3-mediated m⁶A modification controls splicing factor abundance and contributes to CLL progression
Minisymposium: Epigenetics Mechanisms in Cancer, 2:30 – 4:30 p.m. ET
Location: Tangerine Ballroom 3-4, Convention Center
Journal: Blood Cancer Discovery

Oral Presentation: Patient-derived iPSCs faithfully represent the genetic diversity and cellular architecture of human acute myeloid leukemia
Late-Breaking Minisymposium: Late-breaking Research, 2:30 – 4:30 p.m. ET
Location: Room W307, Convention Center
Journal: Blood Cancer Discovery

Oral Presentation: Li Fraumeni Syndrome-associated dimer-forming mutant p53 promotes transactivation-independent mitochondrial cell death
Late-Breaking Minisymposium: Late-breaking Research, 2:30 – 4:30 p.m. ET
Location: Room W307, Convention Center
Journal: Cancer Discovery

Oral Presentation: Molecular determinants of KRAS p.G12C inhibitor efficacy in advanced NSCLC
Minisymposium: Biomarkers of Response in Novel Molecular Therapeutics, 2:30 – 4:30 p.m. ET
Location: Room W414, Convention Center
Journal: Cancer Discovery

Poster Presentations

Poster Presentation: Racial/ethnic disparities in stage at diagnosis among women with cervical cancer in Texas: Mediating effects of neighborhood-level socioeconomic deprivation
Poster Session: Cancer Disparities 1, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 26, Board 4, Presentation 1898
Journal: Cancer Epidemiology, Biomarkers and Prevention

Poster Presentation: FOXA2 induces invasive mucinous adenocarcinoma of the lung in the presence of mutant KRAS
Poster Session: Gene Regulation in Solid Tumors, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 12, Board 6, Presentation 1479
Journal: Cancer Research

Poster Presentation: BZW2 a potential target to inhibit colorectal cancer growth and metastasis
Poster Session: Metastasis Promoting and Suppressing Genes, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 4, Board 20, Presentation 1297
Journal: Molecular Cancer Research

Poster Presentation: Psychosocial stress, social support, and incident breast cancer by estrogen receptor status
Poster Session: Aging, Immune Factors, and Metabolomics, 1:30 – 5 p.m. ET
Poster Location: Section 27, Board 7, Presentation 3011
Journal: Cancer Prevention Research

Poster Presentation: Single-cell spatial analysis identifies regulators of brain tumor initiating cells
Poster Session: Regulation of Stemness: Transformation, Differentiation, and Plasticity, 1:30 – 5 p.m. ET
Poster Location: Section 4, Board 8, Presentation 2435
Journal: Cancer Research

Poster Presentation: RAB27B drives a cancer stem cell phenotype in non-small cell lung cancer cells through enhanced extracellular vesicle secretion
Poster Session: Regulation of Stemness: Transformation, Differentiation, and Plasticity, 1:30 – 5 p.m. ET
Poster Location: Section 4, Board 17, Presentation 2444
Journal: Cancer Research Communications

Poster Presentation: Tumor microenvironment composition correlates with relapse in ovarian granulosa cell tumors
Poster Session: Tumor-Host Interactions and Disease Progression, 1:30 – 5 p.m. ET
Poster Location: Section: 6, Board 11, Presentation 2503
Journal: Molecular Cancer Research

Poster Presentation: Targeting the oxidized form of macrophage migration inhibitory factor (oxMIF) with antibody ON203 activates the tumor microenvironment
Poster Session: Therapeutic Antibodies 3, 1:30 – 5 p.m. ET
Poster Location: Section: 24, Board 21, Presentation 2974
Journal: Molecular Cancer Therapeutics

TUESDAY, APRIL 18

Oral Presentations

Oral Presentation: Revolution in the precision medicine paradigm in phase 1 trials: The future is now
Major Symposium: Future of Phase I Clinical Trials, 12:30 – 2 p.m. ET
Location: Room W311 E-H, Convention Center
Journal: Cancer Discovery

Oral Presentation: Risk factors, trends, and disparities for HPV-associated subsequent malignant neoplasms among adolescent and young adult cancer survivors
Minisymposium: Survivorship and Biomarkers of Prognosis, 2:30 – 4:30 p.m. ET
Location: Room W307, Convention Center
Journal: Cancer Epidemiology, Biomarkers and Prevention

Poster Presentations

Poster Presentation: The polyamine-hypusine circuit controls an oncogenic translational program essential for malignant conversion in MYC-driven lymphoma
Poster Session: Gene Regulation in Cancer, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 9, Board 17, Presentation 3731
Journal: Blood Cancer Discovery

Poster Presentation: A modified FcγRI expressing-T cell, SolidT, enables antibody-mediated cytotoxicity to overcome the limitations of CAR-T cell therapy against solid tumors
Poster Session: Adoptive Cell and Natural Killer Cell Therapy, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 22, Board 27, Presentation 4075
Journal: Cancer Immunology Research

Poster Presentation: Genetic associations with smoking relapse and proportion of follow-up in smoking relapse throughout adulthood in pre- and post-menopausal women
Poster Session: Cancer Screening and Health Equity, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 28, Poster 11, Presentation 4182
Journal: Cancer Prevention Research

Poster Presentation: Identification of membrane-expressed CAPRIN-1 as a novel and universal cancer target, and generation of a therapeutic anti-CAPRIN-1 antibody TRK-950
Poster Session: Identification of Molecular Targets 1, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 17, Board 11, Presentation 3923
Journal: Cancer Research Communications

Poster Presentation: Targeting RET solvent-front mutants with an alkynyl nicotinamide-based inhibitor
Poster Session: Drug Resistance in Molecular Targeted Therapies 3, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 15, Board 1, Presentation 3851
Journal: Molecular Cancer Therapeutics

Poster Presentation: Enhancing adaptive immune responses with telomerase-mediated telomere targeting therapeutics in hepatocellular carcinoma
Poster Session: Developments in Anticancer Immunotherapy, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 25, Board 5, Presentation 4143
Journal: Molecular Cancer Therapeutics

Poster Presentation: Prevalence and prognostic significance of malnutrition in patients with brain metastasis
Poster Session: Diagnostic and Prognostic Biomarkers 4, 1:30 – 5 p.m. ET
Poster Location: Section 40, Board 19, Presentation 5562
Journal: Cancer Epidemiology, Biomarkers and Prevention

Poster Presentation: TONSL is an immortalizing oncogene of the chromosome 8q24.3 amplicon and new therapeutic target in breast cancer
Poster Session: Biomarkers of Therapeutic Benefit 5, 1:30 – 5 p.m. ET
Poster Location: Section 37, Board 8, Presentation 5458
Journal: Cancer Research

Poster Presentation: Spatially resolved transcriptomics deconvolutes histological prognostic subgroups in patients with colorectal cancer and synchronous liver metastases
Poster Session: Single Cell and Spatial Considerations of the Tumor Microenvironment, 1:30 – 5 p.m. ET
Poster Location: Section 7, Board 4, Presentation 4691
Journal: Cancer Research

Poster Presentation: Integrating tumor-intrinsic and immunological factors to identify immunogenic breast cancers from a low-risk cohort; results from the randomized SweBCG91RT trial
Poster Session: Biomarkers of Therapeutic Benefit 5, 1:30 – 5 p.m. ET
Poster Location: Section 37, Board 21, Presentation 5471
Journal: Clinical Cancer Research

Poster Presentation: Dynamics of sequence and structural cell-free DNA landscapes in small-cell lung cancer during systemic therapy
Poster Session: Liquid Biopsies: Circulating Nucleic Acids and Circulating Tumor Cells 4, 1:30 – 5 p.m. ET
Poster Location: Section 41, Board 30, Presentation 5606
Journal: Clinical Cancer Research

Poster Presentation: Duvelisib eliminates CLL B Cells, impairs CLL-supporting cells, and overcomes ibrutinib resistance in a patient-derived xenograft model
Poster Session: Novel Antitumor Agents, PI3K/AKT Inhibitors, Proteasome Inhibitors, and Topoisomerases, 1:30 – 5 p.m. ET
Poster Location: Section 15, Board 11, Presentation 4933
Journal: Clinical Cancer Research

Poster Presentation: Patterns of oncogene co-expression at single cell resolution influence survival in diffuse large B-cell lymphoma
Poster Session: Diagnostic and Prognostic Biomarkers 4, 1:30 – 5 p.m. ET
Poster Location: Section 40, Board 14, Presentation 5557
Journal: Cancer Discovery

Poster Presentation: Targeting kinome reprogramming in ESR1 fusion-driven breast cancer
Poster Session: Targeting Protein Kinases and Phosphatases for Therapy 2, 1:30 – 5 p.m. ET
Poster Location: Section 18, Board 3, Presentation 5011
Journal: Cancer Research

WEDNESDAY, APRIL 19

Poster Presentations

Poster Presentation: BCA101, a novel tumor-targeted bifunctional fusion antibody simultaneously inhibiting EGFR and TGF-β signaling with potential for durable tumor growth inhibition
Poster Session: Anticancer Immunotherapeutics, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 22, Board 15, Presentation 6339
Journal: Cancer Research

Poster Presentation: Met confers radioresistance‐associated aggressiveness through enhancing PLXDC2-mediated cancer stem cell plasticity
Poster Session: Cancer Stem Cells and Therapeutic Resistance, 9 a.m. – 12:30 p.m. ET
Poster Location: Section 1, Board 3, Presentation 5793
Journal: Cancer Research Communications