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AACR CEO Margaret Foti, PhD, MD (hc): Thank you for a spectacular and impactful AACR Annual Meeting 2023
The 114th Annual Meeting of the American Association for Cancer Research featured deep science and a robust multidisciplinary program united by the theme “Advancing the Frontiers of Cancer Science and Medicine,” which reflects the AACR’s commitment to operating at the cutting edge of cancer research and setting a standard for the field that will transform patient outcomes.
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Researchers report first disclosures of 12 novel cancer agents
The AACR Chemistry in Cancer Research working group organized three special sessions at the Annual Meeting that featured first disclosures on the discovery, structure, and mechanism of action of 12 novel cancer agents that have recently entered into phase I clinical trials or will do so in the next few months.
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Researchers discuss myeloid-targeted agents for solid tumors during ASCO joint session
AACR Past President Lisa M. Coussens, PhD, FAACR, and ASCO President Eric P. Winer, MD, FASCO, co-chaired a special session exploring the role of myeloid cells in cancer development and how basic science discoveries are creating opportunities for new therapeutic targets in solid tumors.
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Joint session examines clinico-genomic cancer data initiatives in the U.S. and Japan
The AACR and the Japanese Cancer Association organized a joint session that provided an overview of clinico-genomic cancer data initiatives in the U.S. and Japan and examined some of the challenges that arise when analyzing observational, real-world clinico-genomic data. Kenneth L. Kehl, MD, MPH, and Hiroyuki Mano, MD, PhD, chaired the session.
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Experts discuss insights from latest research into clonal hematopoiesis
Research into clonal hematopoiesis is revealing insights into the initiation of hematologic malignancies, the biology of clonal selection, and the broad consequences of somatic mutations on the function of terminally differentiated blood cells. It’s a “fast-moving field with major clinical implications,” according to session chair Benjamin L. Ebert, MD, PhD.
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Therapeutic response and regulation of metastasis differ by organ site
Experts discussed how the microenvironments of different organ sites regulate metastasis and therapeutic response during an Annual Meeting symposium on Monday, April 17. “There are complex interactions between systemic host responses and the local microenvironments,” said symposium chair Mikala Egeblad, PhD.
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Researchers are targeting RNA splicing machinery to develop novel cancer treatments
Three investigators on the cutting-edge of cancer research — including symposium chair Olga A. Anczuków, PhD — described efforts to target RNA splicing in cancer and the immune system during an Annual Meeting session on Sunday, April16.
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Advances in quantitative sciences driving breakthroughs in cancer research
During a symposium on Monday, April 17, a panel of scientists discussed how they are leveraging quantitative sciences to advance their cancer research. Symposium chair Nagarajan Vaidehi, PhD, discussed her lab’s work using computational methods to study allostery and disordered proteins.