Understanding the genetic and biochemical defects that are required to transform a normal cell into a cancerous cell mass with abnormal growth and an ability to invade other tissues remain a top research focus. Current overlapping research priorities include:
Improvement of cancer prevention and early detection
Mapping of tumor evolution
Developing new technologies to study cancer
MilliporeSigma, the U.S. life science business of Merck KGaA, Darmstadt, Germany offers over 300,000 products enabling scientific discovery, improving quality of life for patients, fostering the success of customers and helping to meet global challenges including a mission to advance cancer and immunology research and therapeutics. We focus on improving everyday lab work as well as engineering break-through technologies to accelerate your productivity in key research areas with our Sigma-Aldrich® antibody and molecular reagents and Millipore® cell culture, sample separation, preparation, and filtration products.
Improving cancer detection
Early cancer detection ultimately translates into more options for patients and better outcomes for many types of cancer. We have developed a comprehensive highly characterized cancer antibody portfolio as well as sensitive immunoassay platforms to enhance research for cancer identification and prevention. Our sample prep products are used extensively in molecular, protein and cellular cancer work.
- Ultra-Sensitive Biomarker Detection Platform
- Tissue Extract Preparation
- Genomic Sample Preparation
- Whole Genome Amplification
Demystify Tumor Biology
While the genetic basis of tumorigenesis may vary between cancer types, the steps, both cellular and molecular, required for metastasis are basically the same. In normal tissue, homeostasis is maintained between epithelial cells and their microenvironment, such as vascular endothelial cells, fibroblasts, immune cells, and the extracellular matrix (ECM). In the cancerous state, these interactions become deregulated. Researching the intricacies of how tumor cells initiate, progress, maintain and reoccur is essential to improving cancer diagnosis and treatment. We offer a wide range of research solutions for uncovering the inner workings of the tumor.
- Multiplex Biomarker Detection
- Proximity Ligation Assays
- Metabolism Kits
- Proteins and Enzymes
- Bioactive Small Molecules
- Cell Culture Tools & Reagents
Harness the Power of Enabling Technologies
Understanding the dynamic nature of cancer tumor initiation and progression requires the study of numerous markers in diverse tissues with some real-time cell analysis. For example, the process of metastasis seems to involve the interplay of ECM degradation, proteolysis, cell adhesion, cell migration, angiogenesis, and tissue homing auguring the need for innovative genomic tools, screening and live cell imaging to manipulate and observe cancer behavior. Apply our enabling tools to streamline discovery, facilitate visualization and enable in-depth insights into cell dynamics.
- Functional Genomic Screening
- Large Scale and High Titer Lentiviral Manufacturing
- Live Cell Imaging
- Automated Cell Counting
With advances in our understanding of the signaling pathways regulating the processes of tumorigenesis and metastasis, together we will one day find novel and better-targeted regimen for the prevention, detection and treatment of cancers worldwide.