To help further the professional advancement of early-career researchers, the American Association for Cancer Research (AACR) launched the NextGen Stars Program in 2014. Each year, graduate students, postdocs, and assistant professors are selected to present their work during highly visible sessions at the AACR Annual Meeting.
This year’s class of NextGen Stars includes 11 individuals spanning different areas of cancer research. Learn more about the work of Jian Carrot-Zhang, PhD, below, and check out Q&As with the other NextGen Stars to discover their research focus.
Jian Carrot-Zhang, PhD
AACR NextGen Stars Class of 2026
Assistant Professor
Memorial Sloan Kettering Cancer Center, New York, New York
Abstract Presentation:
Understand germline determinants of cancer progression using multi-ancestral real-world data
Session Details:
SY18: Genetic and Environmental Determinants of Cancer
Wednesday, April 22, 10:15-11:45 a.m. PT
Room 33 – Upper Level – Convention Center
What is the subject of your research?
My research focuses on germline determinants of cancer progression, particularly how inherited genetic variation shapes the acquisition of somatic alterations and influences tumor evolution and treatment response.
What sparked your interest in this area of research, and why is it important?
My interest was sparked by questions surrounding genetic ancestry and its impact on cancer biology. Differences in germline variation across populations may contribute to disparities in somatic mutation patterns, therapeutic response, and clinical outcomes. Understanding these germline-somatic interactions is essential for advancing equitable precision oncology and ensuring that scientific discoveries benefit diverse populations.
Where would you like to see your area of research be in five years?
In five years, I hope to see the incorporation of population-level germline variation into cancer risk assessment, treatment selection, and therapeutic target development. Integrating germline context into clinical decision-making has the potential to refine precision medicine approaches and improve outcomes across diverse patient groups.
What (or who) inspired you to apply for the NextGen Stars program?
AACR itself inspired me to apply. The organization has consistently fostered rigorous science, collaboration, and mentorship within the cancer research community, making it an ideal environment to engage with leaders and peers across disciplines.
What do you hope to take away from your experience as a NextGen Star and your time at the AACR Annual Meeting?
I hope to gain new perspectives, expand my professional network, and build meaningful collaborations. I also look forward to learning from investigators across disciplines and identifying opportunities to translate germline-somatic research into clinically impactful advances.
